strange with ardour 3

I have been 2 weeks away, I’m a musician. Coming back Ardour 3 behaves strange, on the speaker there is hiss and hum nothing else. It is not only me working on this machine. Input is a edirol and motu ultralite, Ardour in the mix input is okoy, but output is totally gone on headphone or speaker

More importantly, have you made sure you are using the correct audio interface, and that it is still set up correctly?