jamh-
It depends on the RME card. If you are looking at internal PCI cards you can utilize expansion cards to achieve this IIRC. Other cards have ADAT that you could utilize with an external DA, I have a Presonus DigimaxFS I used for this myself. So it still depends a bit.
However all that being said, you might want to look at the Echo Audiofire line of cards if you just need line level input and/or output. The Audiofire 12 has 12 analog inputs and outputs, and would be much better than soldering together your own homegrown solution. I use these all the time for theater sound playback and they work well, though I can’t speak for Linux suport, but I believe they are supposed to be fully supported under FFADO.
You can also link multiple of these together when you need more I/O, again I can’t speak for Linux(Sorry haven’t tried one under Linux) but it should be possible.
Seablade