With the latest kernel, 4.8.0, on Ubuntu 16.10, I here clicking during playback in Ardour’s monitor. Up until recently I could boot into an older kernel, 4.4.0, and playback would work fine.
Oddly, if I export the project and listen in something else, like VLC, the audio sounds fine.
I have tried this with ALSA and Jack/ALSA. I am using an older Alesis MultiMix8 FireWire.
Any ideas on how to clear this up?